Compounds > 4-hydroxy-3-(4-hydroxyphenyl)-5-methoxy-8,8-dimethyl-6-(3-methylbut-2-enyl)-2-pyrano[2,3-h][1]benzopyranone
Page last updated: 2024-11-13

4-hydroxy-3-(4-hydroxyphenyl)-5-methoxy-8,8-dimethyl-6-(3-methylbut-2-enyl)-2-pyrano[2,3-h][1]benzopyranone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID54676535
CHEMBL ID1603825
CHEBI ID93435
SCHEMBL ID12062082

Synonyms (38)

Synonym
BRD-K81847782-001-02-1
KBIO1_001385 ,
DIVK1C_006441
SDCCGMLS-0066849.P001
BSPBIO_003003
SPECTRUM_000746
SPECTRUM5_000117
NCGC00178349-01
NCGC00095595-01
KBIO3_002223
KBIOGR_002017
KBIOSS_001226
KBIO2_001226
KBIO2_003794
KBIO2_006362
SPECTRUM3_001312
SPECTRUM2_001906
SPECTRUM4_001469
SPBIO_001872
SPECPLUS_000345
SPECTRUM300348
scandenin
LMPK12160022
NCGC00095595-02
CCG-38477
bdbm50442909
chembl1603825 ,
SCHEMBL12062082
2h,8h-benzo[1,2-b:3,4-b']dipyran-2-one, 4-hydroxy-3-(p-hydroxyphenyl)-5-methoxy-8,8-dimethyl-6-(3-methyl-2-butenyl)-
AAKJUGSASOCUFQ-UHFFFAOYSA-N
2h,8h-benzo[1,2-b:3,4-b']dipyran-2-one, 4-hydroxy-3-(4-hydroxyphenyl)-5-methoxy-8,8-dimethyl-6-(3-methyl-2-butenyl)-
4-hydroxy-3-(4-hydroxyphenyl)-5-methoxy-8,8-dimethyl-6-(3-methyl-2-butenyl)-2h,8h-pyrano[2,3-f]chromen-2-one #
5084-00-4
CHEBI:93435
Q27165133
4-hydroxy-3-(4-hydroxyphenyl)-5-methoxy-8,8-dimethyl-6-(3-methylbut-2-enyl)-2-pyrano[2,3-h][1]benzopyranone
DTXSID901340105
4-hydroxy-3-(4-hydroxyphenyl)-5-methoxy-8,8-dimethyl-6-(3-methyl-2-buten-1-yl)-2h,8h-benzo[1,2-b:3,4-b']dipyran-2-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
isoflavonoidAny 1-benzopyran with an aryl substituent at position 3. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (28)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency22.38720.004023.8416100.0000AID485290
Chain A, HADH2 proteinHomo sapiens (human)Potency31.62280.025120.237639.8107AID893
Chain B, HADH2 proteinHomo sapiens (human)Potency31.62280.025120.237639.8107AID893
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency35.48130.177814.390939.8107AID2147
USP1 protein, partialHomo sapiens (human)Potency79.43280.031637.5844354.8130AID504865
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency39.81070.011212.4002100.0000AID1030
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency44.66840.354828.065989.1251AID504847
DNA polymerase kappa isoform 1Homo sapiens (human)Potency44.66840.031622.3146100.0000AID588579
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency19.95260.031610.279239.8107AID884; AID885
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency31.62280.251215.843239.8107AID504327
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
GABA theta subunitRattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)IC50 (µMol)0.74130.10472.71957.0795AID977603
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)Ki0.56000.08002.46889.8000AID977604
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)IC50 (µMol)1.07150.05002.37979.7000AID977600
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)Ki0.59000.04401.36305.0000AID977601
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (9)

Processvia Protein(s)Taxonomy
xenobiotic metabolic processSolute carrier organic anion transporter family member 1B3Homo sapiens (human)
monoatomic ion transportSolute carrier organic anion transporter family member 1B3Homo sapiens (human)
organic anion transportSolute carrier organic anion transporter family member 1B3Homo sapiens (human)
bile acid and bile salt transportSolute carrier organic anion transporter family member 1B3Homo sapiens (human)
heme catabolic processSolute carrier organic anion transporter family member 1B3Homo sapiens (human)
sodium-independent organic anion transportSolute carrier organic anion transporter family member 1B3Homo sapiens (human)
transmembrane transportSolute carrier organic anion transporter family member 1B3Homo sapiens (human)
xenobiotic metabolic processSolute carrier organic anion transporter family member 1B1Homo sapiens (human)
monoatomic ion transportSolute carrier organic anion transporter family member 1B1Homo sapiens (human)
organic anion transportSolute carrier organic anion transporter family member 1B1Homo sapiens (human)
bile acid and bile salt transportSolute carrier organic anion transporter family member 1B1Homo sapiens (human)
prostaglandin transportSolute carrier organic anion transporter family member 1B1Homo sapiens (human)
heme catabolic processSolute carrier organic anion transporter family member 1B1Homo sapiens (human)
sodium-independent organic anion transportSolute carrier organic anion transporter family member 1B1Homo sapiens (human)
transmembrane transportSolute carrier organic anion transporter family member 1B1Homo sapiens (human)
thyroid hormone transportSolute carrier organic anion transporter family member 1B1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (6)

Processvia Protein(s)Taxonomy
serine-type endopeptidase inhibitor activitySolute carrier organic anion transporter family member 1B3Homo sapiens (human)
organic anion transmembrane transporter activitySolute carrier organic anion transporter family member 1B3Homo sapiens (human)
bile acid transmembrane transporter activitySolute carrier organic anion transporter family member 1B3Homo sapiens (human)
sodium-independent organic anion transmembrane transporter activitySolute carrier organic anion transporter family member 1B3Homo sapiens (human)
organic anion transmembrane transporter activitySolute carrier organic anion transporter family member 1B1Homo sapiens (human)
bile acid transmembrane transporter activitySolute carrier organic anion transporter family member 1B1Homo sapiens (human)
prostaglandin transmembrane transporter activitySolute carrier organic anion transporter family member 1B1Homo sapiens (human)
sodium-independent organic anion transmembrane transporter activitySolute carrier organic anion transporter family member 1B1Homo sapiens (human)
thyroid hormone transmembrane transporter activitySolute carrier organic anion transporter family member 1B1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
plasma membraneGamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)
plasma membraneGamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)
plasma membraneGamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)
plasma membraneSolute carrier organic anion transporter family member 1B3Homo sapiens (human)
basal plasma membraneSolute carrier organic anion transporter family member 1B3Homo sapiens (human)
basolateral plasma membraneSolute carrier organic anion transporter family member 1B3Homo sapiens (human)
plasma membraneSolute carrier organic anion transporter family member 1B1Homo sapiens (human)
basal plasma membraneSolute carrier organic anion transporter family member 1B1Homo sapiens (human)
membraneSolute carrier organic anion transporter family member 1B1Homo sapiens (human)
basolateral plasma membraneSolute carrier organic anion transporter family member 1B1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (44)

Assay IDTitleYearJournalArticle
AID1081926Insecticidal activity against 3 to 8 days old Rhyzopertha dominica assessed as mortality at 1 ug/mL measured after 72 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1081925Insecticidal activity against 3 to 8 days old Rhyzopertha dominica assessed as mortality measured after 24 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID977603pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1081930Insecticidal activity against 3 to 8 days old Sitophilus oryzae (rice weevil) assessed as mortality at 1 ug/mL measured after 72 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1081927Insecticidal activity against 3 to 8 days old Rhyzopertha dominica assessed as mortality at 1 ug/mL measured after 48 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1104292Toxicity against Achaea janata at 10 ug/cm2 after 24 hr by leaf disk method2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1104285Insecticidal activity against Achaea janata assessed as pupal duration at 2 ug/larva administered through topical application (Rvb = 10.3 +/- 0.1 days)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1081934Insecticidal activity against 3 to 8 days old Callosobruchus chinensis assessed as mortality at 1 ug/mL measured after 72 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1104281Insecticidal activity against Achaea janata assessed as pupal mortality at 2 ug/larva administered through topical application2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1081932Insecticidal activity against 3 to 8 days old Sitophilus oryzae (rice weevil) assessed as mortality at 1 ug/mL measured after 24 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1104290Insecticidal activity against Achaea janata assessed as larval duration at 4 ug/larva administered through topical application (Rvb = 7.3 +/- 0.1 days)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1104289Insecticidal activity against Achaea janata assessed as larval mortality at 2 ug/larva administered through topical application2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID977599Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID977600pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1104291Insecticidal activity against Achaea janata assessed as larval duration at 2 ug/larva administered through topical application (Rvb = 7.3 +/- 0.1 days)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1081928Insecticidal activity against 3 to 8 days old Rhyzopertha dominica assessed as mortality at 1 ug/mL measured after 24 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1104283Insecticidal activity against Achaea janata assessed as pupal weight at 2 ug/larva administered through topical application (Rvb = 696.4 +/- 2.6 mg)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1104288Insecticidal activity against Achaea janata assessed as larval mortality at 4 ug/larva administered through topical application2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1104286Insecticidal activity against Achaea janata assessed as pupal duration at 4 ug/larva administered through topical application (Rvb = 10.3 +/- 0.1 days)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1104279Insecticidal activity against Achaea janata assessed as adult deformity at 2 ug/larva administered through topical application2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1081922Insecticidal activity against 3 to 8 days old Tribolium castaneum (red flour beetle) assessed as mortality at 1 ug/mL measured after 72 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1081921Insecticidal activity against 3 to 8 days old Tribolium castaneum (red flour beetle) assessed as mortality measured after 24 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1081923Insecticidal activity against 3 to 8 days old Tribolium castaneum (red flour beetle) assessed as mortality at 1 ug/mL measured after 48/ hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1104295Antifeedant activity against Achaea janata at 1 ug/cm2 by conventional no-choice disk method2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1081924Insecticidal activity against 3 to 8 days old Tribolium castaneum (red flour beetle) assessed as mortality at 1 ug/mL measured after 24 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1081933Insecticidal activity against 3 to 8 days old Callosobruchus chinensis assessed as mortality measured after 72 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID977602Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1104280Insecticidal activity against Achaea janata assessed as adult deformity at 4 ug/larva administered through topical application2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1081935Insecticidal activity against 3 to 8 days old Callosobruchus chinensis assessed as mortality at 1 ug/mL measured after 48 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1104277Insecticidal activity against Achaea janata assessed as adult emergence at 2 ug/larva administered through topical application (Rvb = 98.8 +/- 0.5 %)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1104284Insecticidal activity against Achaea janata assessed as pupal weight at 4 ug/larva administered through topical application (Rvb = 696.4 +/- 2.6 mg)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1104294Toxicity against Achaea janata after 24 hr by leaf disk method2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1104296Antifeedant activity against Achaea janata at 2 ug/cm2 by conventional no-choice disk method2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1104278Insecticidal activity against Achaea janata assessed as adult emergence at 4 ug/larva administered through topical application (Rvb = 98.8 +/- 0.5 %)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1081929Insecticidal activity against 3 to 8 days old Sitophilus oryzae (rice weevil) assessed as mortality measured after 72 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1081936Insecticidal activity against 3 to 8 days old Callosobruchus chinensis assessed as mortality at 1 ug/mL measured after 24 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID977604Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1081931Insecticidal activity against 3 to 8 days old Sitophilus oryzae (rice weevil) assessed as mortality at 1 ug/mL measured after 48 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1104297Antifeedant activity against Achaea janata by conventional no-choice disk method2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID977601Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1104299Antifeedant activity against Achaea janata at 10 ug/cm2 by conventional no-choice disk method2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1104282Insecticidal activity against Achaea janata assessed as pupal mortality at 4 ug/larva administered through topical application2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID1159550Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening2015Nature cell biology, Nov, Volume: 17, Issue:11
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.28

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.28 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.28)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
osajin
osajin: from Maclura pomifera		2.4620isoflavanones
genistein
[no description available]		2.46207-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
warangalone
warangalone: structure in first source		2.4620
lupalbigenin
lupalbigenin: has antineoplastic activity; isolated from Derris scandens; structure in first source		2.4620isoflavanones
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		03.0310
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.0310
Anemia, Fanconi
[description not available]		02.1310
Fanconi Anemia
Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)		02.1310